Affected growth treatment with green tea reviews

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Growth hormone treatments work better on some children than on others, but judging which candidates will gain those vital inches in height is no simple task. Now researchers have developed a new mathematical model which predicts the optimal dose of growth hormone to treat children who are abnormally short for a wide range of reasons. A new study describes a model that can be more widely applied than previous versions, with greater predictive accuracy.

Jovanna Dahlgren and colleagues at Gothenburg University in Sweden analysed data from 415 short prepubertal children who had undergone GH treatment to develop a model that predicts an individual's response. The team gathered data including the children's length and weight at birth, height before and during treatment and their parents' height. The model was then validated by applying it to a group of 112 different children. The model's accuracy was substantially improved by including data on blood levels of growth hormone and other growth-related hormones, such as insulin-like growth factors and leptin.

Dr Dahlgren states, "The models presented serve as a practical clinical tool for selecting children for successful growth hormone treatment ... and provide the highest prediction accuracy available."

Growth hormone treatments are expensive, involve daily injections, and are associated with the risk of overdose. To assess whether growth hormone treatment would be appropriate for a particular child, an accurate prediction of how much growth would result from the treatment is crucial. This new research will help clinicians determine the children most likely to benefit from treatment, and the most appropriate dose.

Journal reference: Jovanna Dahlgren, Berit Kristrom, Aimon Niklasson, Andreas FM Nierop, Sten Rosberg, Kerstin Albertsson-Wikland. Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age.

Antifibrotic Effects of Green Tea

Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. However, the hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models has not been studied.

A research article published on November 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team, led by Prof. Hong-Yon Cho from Korea University examined the protective effect of green tea extract (GT) on hepatic fibrosis in a rat HSC line and in a rat model of DMN-induced hepatic fibrosis.

The results showed GT administration prevented the development of hepatic fibrosis in the rat model of DMN-induced liver fibrosis. These results were confirmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content, a marker of liver collagen deposition. Accordingly, inhibition of proliferation, reduced collagen deposition, and type 1 collagen expression were observed in activated HSC-T6 cells following GT treatment. These results imply that GT reduced the proliferation of activated HSC and down regulated the collagen content and expression of collagen type 1, thereby ameliorating hepatic fibrosis.

The researchers drew a conclusion that green tea may protect liver cells and reduce the deposition of collagen fibers in the liver. Green tea provides a safe and effective strategy for improving hepatic fibrosis.

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